Fluconazole has been demonstrated to show fungi static activity against the majority of strains of the following microorganisms, curing fungal infections by susceptible strains of Candida, Tinea corporis, Tinea cruris or Tinea pedis, Onychomycosis and Cryptococcal meningitis. This is achieved through steroidal inhibition in fungal cells, interfering with cell wall synthesis and growth as well as cell adhesion, thereby treating fungal infections and their symptoms. Mode of Action: Fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent accumulation of 14α-methyl sterols. As ergosterol forms a critical part of the fungal cell membrane, fluconazole inhibits the synthesis of ergosterol to increase cellular permeability. Other functions of the medication are to prevent endogenous respiration and the formation of yeasts. It is also noteworthy to reiterate that the loss of sterols goes parallel with the accumulation of 14—methyl sterols found in fungi and is the primary cause of the perceived fungistatic activity of fluconazole.   Mammalian demethylation is less sensitive to fluconazole inhibition; therefore, using fluconazole helps the body counteract the causative agents of fungal infection.

Mycotic keratitis, C. parapsilosis keratitis, otomycosis, fungal infections by susceptible strains of Candida, Tinea corporis, Tinea cruris or Tinea pedis, Onychomycosis and Cryptococcal meningitis.

Instil 1-2 drops in the affected eye(s)/ear 3 times a day or as directed by the Physician

• Remove contact lenses 15 mins before administration.
• Discuss with your physician if pregnant or breast feeding before usage.
• Causes Blurred vision, do not do tasks that require clear vision.
• If solution changes colour or becomes cloudy, do not use.

Side Effects: Use of Fluconazole 0.3% Eye Drops may cause dizziness, head ache, change in taste and nausea.