PHARMACOLOGY- AMBIFEN PLUS SUSPENSION is formulated with a novel combination of two active components i.e. IBUPROFEN and PARACETAMOL an NSAID with analgesic used for the treatment of fever, mild to moderate pain and inflammation. The combination blocks the chemicals in the body that are responsible to cause fever, pain and inflammation. As per literary data combination is formulated because it gives better effect rather than individual use of both. IBUPROFEN-IBUPROFEN is a prototypical non steroidal anti-inflammatory agent medication having analgesic and antipyretic properties too derived from propionic acid used primarily in the treatment of fever, mild to moderate pain such as dental pain, headache, pain from kidney stones and painful menstruation. The mode of action of IBUPROFEN is not known exactly but as anti-inflammatory it functions by inhibiting cyclooxygenase enzyme that decreases the synthesis of prostaglandins via arachidonic acid pathway which is the main cause of inflammatory condition such as pain, swelling and redness. As antipyretic it directly acts on hypothalamus as a result peripheral blood flow increases due to which vasodilation and subsequent heat dissipation occurs.   PARACETAMOL- As analgesic PARACETAMOL thought to act on central nervous system,               reduces pain by inhibiting COX enzymes such as COX-1, COX-2 and COX-3. Unlike NSAIDS it does     not show any kind of action on peripheral tissues that’s why not act as anti-inflammatory is. Antipyretic effect of PARACETAMOL is explained by the direct effect of heat-regulating centre of hypothalamus as a results peripheral dilation and sweating occurs which cause heat dissipation.

AMBIFEN Plus SUSPENSION is indicated to use for the following conditions-

• Fever,
• Headache,
• Patent Ductus Arteriosus (PDA),
• Muscular Pain,
• Dental Pain,
• Nerve Pain

CHILDREN 2-4 YEARS- Take 5ml three times a day CHILDREN 4-7 YEARS- Take 7.5ml three times a day CHILDREN 4-7 YEARS- Take 10ml three times a day NOTE- Dose also depends on the body weight of the children. So give dose as prescribed by practitioner.

WARNING AND PRECAUTIONS- Before using this medicament tell your doctor if you have any kind of allergies from antipyretic or analgesic or other NSAID. This medicine may contain inactive ingredients which also cause allergy if it occurs then contact to your doctor. ADVERSE EFFECTS-

• increased sweating.
• loss of appetite.
• nausea or vomiting.
• stomach cramps or pain.
• swelling, pain, or tenderness in the upper abdomen or stomach area.