Ednol consists of Loteprednol Etabonate which is a “soft” steroid that belongs to the class of Glucocorticoids. At molecular level, unbound Glucocorticoids readily cross cell membranes and bind with high affinity (Affinity is gerater when compared with other Glucocorticoids), to specific Cytoplasmic receptors. This binding induces a response by modifying transcription and, ultimately protein synthesis to achieve the formation of Anti-Inflammatory Protein that inhibits the enzyme Phospholipase A2 which is needed in supply of Arachidonic acid. The latter is responsible for the formation of the mediators of inflammatory causing mediators. Thus inhibits the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation with inflammation.

Ednol is indicated for the treatment of steroid responsive inflammatory conditions of the eye such as Allergic Conjunctivitis, Giant Papillary Conjunctivitis, Anterior Uveitis, Acne Rosacea, Superficial Punctuate Keratitis, Herpes Zoster Keratitis, Iritis, and In Post Operative Pain & Inflammation.

• As per the literary data, Loteprednol Etabonate is contraindicated in patients with ocular infections due to Acanthamoeba, herpes simplex virus, and fungi.
• Use cautiously for Glaucoma patients.
• Contraindicated to patients with hypersensitivity towards Loteprednol Etabonate.
• Prolonged used may increase the risk of corneal fungal infection.
• If the present symptoms pertains consult the Eye Doctor.

Adverse Effect: Abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.