Class: Immuno-Modulator and Anti-Allergic
Pharmacology:
Acrotak Eye Ointment contains 0.03% Tacrolimus also known as FK 506 is a macrolide derivative with anti-inflammatory and immunomodulatory activity. Tacrolimus is produced by the fungus Streptomyces tsukubaenis can suppress the T cell activation and interleukin-2 production by binding to an immunophilin and inhibiting the enzymatic activity of calcineurin. This inactivation of Calcineurin suppresses formation of T helper 1 (Th1) (interleukin (IL)-2, interferon γ) and Th2 cytokines (IL-4, IL-5).Tacrolimus has also been reported to inhibit histamine release from mast cells and is thought to alleviate allergic symptoms through these mechanisms.
Why it is a better choice
- Safe, Effective and well tolerated
- Slow absorption from conjunctive gives better therapeutic results
- Controlled IOP Levels unlike steroids
- Most preferred anti allergic over steroids